Dr. Zeng Yandun explained that target drugs are "biological drugs", which are produced by living cells, which are very different from traditional drugs that everyone is familiar with, and the cost of target drugs is relatively high. The manufacturing process of biopharmaceuticals is very complicated. It is necessary to implant specific DNA sequences into living cells first, and let the living cells produce amino acid sequences based on the DNA. The amino acid sequences are further combined into antibodies, also known as monoclonal antibodies. These antibodies can bind to specific receptors on cancer cells and affect cell performance.
Traditional drugs are synthesized by a telemarketing list series of chemical reactions, usually composed of dozens of atoms, which can be written as chemical formulas; biological drugs are composed of hundreds of amino acids, up to 25,000 atoms. 100 to 1,000 times larger, and must also have the right quaternary structure to function. Because biological drugs only bind to cancer cells with specific receptors, the effect is more precise, and it is called targeted therapy. Chemotherapy drugs kill cancer cells, but they also affect healthy cells, causing more and more pronounced side effects. Biosimilar and generic drugs are different Dr. Zeng Yandun pointed out that the clinical use of biological drugs is becoming more and more extensive, and the patents of various drugs are also expiring, so other pharmaceutical companies can develop biosimilar drugs based on reference drugs.
Because the pharmaceutical company needs to perform a series of detailed analyses on the reference drug first, the DNA sequence is implanted into living cells, and the antibodies are produced by the living cells. Because the process needs to be re-developed and the cell lines used are different, the biopharmaceuticals produced are similar in structure, with equal efficacy and safety, so they are called "biosimilar drugs". 02 In the face of breast cancer, don't give up treatment for financial pressure-Finished-03 Photo Credit: Care Online Biosimilar drugs are not the scientific name drugs of traditional drugs. The production process of biosimilar drugs is much more complicated than that of traditional chemical drugs, and clinical trials need to be completed to confirm that the drug properties, efficacy and safety are equal to those of reference drugs.